منابع مشابه
Dmd053322 2018..2023
In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the observed values. The exceptions involve...
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Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer’s disease. A human absorption, distribution, metabolism, and excretion study was conducted to gain further understanding of the metabolism and disp...
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Tissue homeostasis is maintained by adult stem cells, which selfrenewand give rise to differentiating cells. The generation of daughter cells with different fates is mediated by signalling molecules coming from an external niche or being asymmetrically dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate ...
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Its statutes give the IEG the task of conducting research into the traditions, transformations and crises especially of religious, political and social differentiations, their effects, and the possibilities for overcoming them. This mandate was fulfilled with the central theme of the research programme from 2012 to 2017, »negotiating differences in Europe«, by applying it to an interdepartmenta...
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In CANDECOMP/PARAFAC tensor decomposition, degeneracy often occurs in some difficult scenarios, e.g., when the rank exceeds the tensor dimension, or when the loading components are highly collinear in several or all modes, or when CPD does not have an optimal solution. In such the cases, norms of some rank-1 terms become significantly large, and cancel each other. This makes algorithms getting ...
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ژورنال
عنوان ژورنال: BDJ team
سال: 2023
ISSN: ['2054-7617']
DOI: https://doi.org/10.1038/s41407-023-1747-z